ScienceDaily (Jun. 22, 2007)

People who drink coffee are less likely to develop an involuntary eye spasm called primary late onset blepharospasm, which makes them blink uncontrollably and can leave them effectively 'blind', according to a new study.

The effect was proportional to the amount of coffee drank and one to two cups per day were needed for the protective effect to be seen. The age of onset of the spasm was also found to be later in patient who drank more coffee -- 1.7 years for each additional cup per day.

Previous studies have suggested that smoking protects against development of blepharospasm, but this Italian study did not show a significant protective effect.

Late onset blepharospasm is a dystonia in which the eyelid muscles contract uncontrollably; this starts as involuntary blinking but in extreme cases sufferers are rendered functionally blind despite normal vision because they are unable to prevent their eyes from clamping shut.

The study involved 166 patients with primary late onset blepharospasm, 228 patients with hemifacial spasm (a similar muscle spasm that usually begins in the eyelid muscles but then spreads to involve other muscles of the face) and 187 people who were relatives of patients. The second two groups acted as controls.

The participants were recruited through five hospitals in Italy and asked whether they had ever drank coffee or smoked and for how many years. They were also asked to estimate how many cups of coffee they drank and/or packs of cigarettes they smoked per day. The age of onset of muscle spasms was recorded for patients who experienced them and a reference age was calculated for each of the patients' relatives based on the duration of the spasms in the other group.

Regression analysis was used to observe the relationship between coffee drinking and smoking on the development of blepharospasm.

The authors say: 'Our findings raise doubt about the association of smoking and blepharospasm but strongly suggest coffee as a protective factor.'

'The most obvious candidate for the protective effect is caffeine, but the low frequency of decaffeinated coffee intake in Italy prevented us from examining the effects of caffeine on blepharospasm.

They suggest that caffeine blocks adenosine receptors as has been proposed for its mechanism in protecting against Parkinson's disease.

The authors estimate that people need to drink one to two cups of coffee per day for the protective effect to be seen.

'Considering that the caffeine content of a cup of Italian coffee (60--120 mg) is similar to the average content of a cup of American coffee (95--125 mg), the protective effect on the development of blepharospasm might be exerted at caffeine doses greater than 120--240 mg, comparable with the caffeine doses suggested to be protective in Parkinson's disease,' they say.

This research was published online ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.

Adapted from materials provided by BMJ Specialty Journals.